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As most RCTs were designed to evaluate metabolic or cardiovascular outcomes rather than cancer endpoints, their follow-up periods may be insufficient to fully capture the latency of solid tumor development

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Declarations Acknowledgement This bioinformatics-assisted review is part of Project ATA (NCT05758311), developed and supported by the Research Division of the Dynamical Business & Science SocietyDBSS International SAS

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As the expression levels of OCTN2 and ATB 0,+ are higher in colon cancer cells than in normal colon cells, LC-PLGA NPs can be used to deliver chemotherapeutic drugs selectively to cancer cells for colon cancer therapy